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doi: 10.3389/fncel.2020.00163, 76 KhlerS.SchmidtH.FlleP.HirrlingerJ.WinklerU

Hum Reprod Oxf Engl (2016) 31:92637

Support for an allosteric role of BH4 was confirmed by spectrophotometric and electron paramagnetic resonance (EPR) studies, which show that BH4 binding converts the heme iron from a low-spin to a high-spin state [30]